Risedronate and methotrexate are high-affinity inhibitors of New Delhi Metallo-β-Lactamase-1 (NDM-1): a drug repurposing approach

G Muteeb, A Alsultan, M Farhan, M Aatif - Molecules, 2022 - mdpi.com
Bacteria expressing New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze β-lactam
antibiotics (penicillins, cephalosporins, and carbapenems) and, thus, mediate multidrug …

High-throughput virtual screening, molecular dynamics simulation, and enzyme kinetics identified ZINC84525623 as a potential inhibitor of NDM-1

MT Rehman, MF AlAjmi, A Hussain, GM Rather… - International journal of …, 2019 - mdpi.com
The bacteria expressing New Delhi Metallo-β-lactamase-1 (NDM-1) can hydrolyze all β-
lactam antibiotics including carbapenems, causing multi-drug resistance. The worldwide …

[HTML][HTML] Molecular Modeling and simulation-based identification of inhibitors against new Delhi Metallo-Lactamase 1: Implications for bacterial antibiotic resistance

S Haque, DM Mathkor, AK Johargy, H Faidah… - Journal of King Saud …, 2024 - Elsevier
Abstract Objectives Bacterial infections expressing New Delhi metallo-lactamase-1 (NDM-1)
pose an escalating global threat to healthcare systems. NDM-1 is an enzyme that renders β …

[HTML][HTML] The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018

X Gu, M Zheng, L Chen, H Li - Microbiological Research, 2022 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

Identification of a potential inhibitor for New Delhi metallo-β-lactamase 1 (NDM-1) from FDA approved chemical library-a drug repurposing approach to combat …

A Fasim, SS More - Journal of Biomolecular Structure & Dynamics, 2022 - europepmc.org
Superbugs producing New Delhi metallo-β-lactamase 1 (NDM-1) enzyme is a growing
crisis, that is adversely affecting the global health care system. NDM-1 empowers the …

Identification of a potential inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) using in silico and in vitro approaches

G Muteeb, MT Rehman, MF AlAjmi, M Aatif, M Farhan… - Molecules, 2022 - mdpi.com
New Delhi metallo-β-lactamase-1 (NDM-1), expressed in different Gram-negative bacteria,
is a versatile enzyme capable of hydrolyzing β-lactam rings containing antibiotics such as …

Inhibitor discovery of full-length New Delhi metallo-β-lactamase-1 (NDM-1)

B Shen, Y Yu, H Chen, X Cao, X Lao, Y Fang, Y Shi… - PLoS …, 2013 - journals.plos.org
New Delhi metallo-β-lactmase-1 (NDM-1) has recently attracted extensive attention for its
biological activities to catalyze the hydrolysis of almost all of β-lactam antibiotics. To study …

Inhibitor and substrate binding by New Delhi metallo-beta-lactamase-1: a molecular dynamics studies

YT Wang, CY Lu, TC Hour… - Current computer-aided …, 2014 - ingentaconnect.com
The control of beta-lactam antibiotics released through the inhibition of the New Delhi
metallo-beta-lactamase 1 (NDM-1) has been identified as a potential target for the treatment …

[HTML][HTML] Binding selectivity analysis of new delhi metallo-beta-lactamase-1 inhibitors using molecular dynamics simulations: Exploring possibilities for decoding …

S Haque, F Ahmad, DM Mathkor, H Makhdoom… - Journal of Infection and …, 2024 - Elsevier
Abstract Background New Delhi metallo-beta-lactamase-1 (NDM1) confers resistance to
several bacterial species against a broad range of beta-lactam antibiotics and turning them …

Structure-based virtual screening for the discovery of novel inhibitors of New Delhi metallo-β-lactamase-1

F Spyrakis, G Celenza, F Marcoccia… - ACS medicinal …, 2018 - ACS Publications
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-
lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance …