The breast cancer type 1 susceptibility protein (BRCA1) and its partner–the BRCA1-
associated RING domain protein 1 (BARD1)–are key players in a plethora of fundamental …

The breast cancer susceptibility protein 1 (BRCA1) participates in the maintenance of cells
genomic integrity through DNA repair, cell cycle checkpoint, protein ubiquitination, and …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

The breast-and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous
cellular processes, including transcription, ubiquitination, and DNA repair. Its tumor …

Breast cancer susceptibility gene 1 (BRCA1)-associated RING domain (BARD1) was
discovered as a protein interacting with the RING domain of BRCA1. It is structurally …

Current oncological developments are based on improved understanding of genetics, and
especially the discovery of genes whose alterations affect cell functions with consequences …

Br east Ca ncer 1 (BRCA1) gene is a well-characterized tumor suppressor gene, mutations
of which are primarily found in women with breast and ovarian cancers. B RCA1-a ssociated …

Breast cancer 1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1) are multidomain
proteins that interact in vivo via their N-terminal RING finger motif regions. To characterize …

To preserve genome stability, BRCA1 must be recruited to sites of DNA damage, where
BRCA1 facilitates repair of double-strand DNA breaks (DSBs). In this issue of Cancer Cell, Li …

Carriers of BRCA1 germline mutations are predisposed to breast and ovarian cancers.
Accumulated evidence shows that BRCA1 is quickly recruited to DNA lesions and plays an …