[HTML][HTML] Artemisinin resistance and malaria elimination: Where are we now?

B Hanboonkunupakarn, J Tarning… - Frontiers in …, 2022 - frontiersin.org
The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is …

Unpacking 'artemisinin resistance'

J Wang, C Xu, ZR Lun, SR Meshnick - Trends in Pharmacological Sciences, 2017 - cell.com
Artemisinin and its derivatives, in combination with partner drugs, are currently the most
effective treatments for malaria parasite infection. Even though artemisinin has been widely …

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

RT Eastman, DA Fidock - Nature Reviews Microbiology, 2009 - nature.com
Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

A brief history of artemisinin: Modes of action and mechanisms of resistance

LU Feng, HE Xin-Long, C Richard, CAO Jun - Chinese journal of natural …, 2019 - Elsevier
The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated
morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced …

Artemisinin antimalarials: preserving the “magic bullet”

RJ Maude, CJ Woodrow… - Drug development …, 2010 - Wiley Online Library
The artemisinins are the most effective antimalarial drugs known. They possess a
remarkably wide therapeutic index. These agents have been used in traditional Chinese …

Drug-resistant malaria: the era of ACT

JT Lin, JJ Juliano, C Wongsrichanalai - Current infectious disease reports, 2010 - Springer
As drug-resistant falciparum malaria has continued to evolve and spread worldwide,
artemisinin-based combination therapies (ACT) have become the centerpiece of global …

[HTML][HTML] Resistance to artemisinin combination therapies (ACTs): do not forget the partner drug!

C Nsanzabana - Tropical medicine and infectious disease, 2019 - mdpi.com
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

Pharmacotherapy for artemisinin-resistant malaria

E Koehne, AA Adegnika, J Held… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Malaria, the most devastating parasitic disease, is currently treated with
artemisinin-based combination therapies (ACTs). Unfortunately, some ACTs are unable to …

[HTML][HTML] Artemisinin-resistant malaria: research challenges, opportunities, and public health implications

RM Fairhurst, GML Nayyar, JG Breman… - The American journal …, 2012 - ncbi.nlm.nih.gov
Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium
falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the …

Discovery, mechanisms of action and combination therapy of artemisinin

L Cui, X Su - Expert review of anti-infective therapy, 2009 - Taylor & Francis
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …