Glutathione transferases (GSTs; EC 2.5. 1.18) form a group of multifunctional enzymes that
are involved in phase II of the cellular detoxification mechanism and are associated with …

Glutathione transferases (GSTs; EC 2.5. 1.18) form a group of multifunctional enzymes that
are involved in phase II cellular detoxification mechanism. Here, screening of the inhibition …

ABSTRACT Glutathione transferase-P1-1 (hGSTP1-1), which is associated with acquired
drug resistance in some tumour cells, requires two identical subunits for full activity …

Human glutathione transferase A1-1 (hGSTA1-1) contributes to developing resistance to
anticancer drugs and, therefore, is promising in terms of drug-design targets for coping with …

Abstract Glutathione transferases (GST, EC. 2.5. 1.18) are overexpressed in cancer cell and
have been shown to be involved in cancer cell growth, differentiation and the development …

Multidrug resistance is a significant barrier that makes anticancer therapies less effective.
Glutathione transferases (GSTs) are involved in multidrug resistance mechanisms and play …

Glutathione transferase Pi (GSTP1) expression is increased in many cancer types and is
associated with multidrug resistance and apoptosis inhibition. Inhibitors of GSTP1-1 have …

Glutathione transferases (EC 2.5. 1.18, GSTs) catalyze the nucleophilic attack of glutathione
(GSH) on the electrophilic centre of a number of electrophilic compounds helping to detoxify …

Results Two new polymorphisms were detected and characterized in the GSTM3 gene. A
rare pG147W substitution was detected only in the Southern Chinese subjects. A more …

Glutathione transferases (GSTs) are a family of enzymes that detoxify electrophilic
compounds, such as carcinogens or drugs, by conjugating them to glutathione. The …