Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during
mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows …

The journey of embryonic development starts at oocyte fertilization, which triggers a complex
cascade of events and cellular pathways that guide early embryogenesis. Recent …

The first cell cycles following in vitro fertilization (IVF) of human gametes are prone to
chromosome instability. Many, but often not all, blastomeres of an embryo acquire a genetic …

Mitotic errors are common in human preimplantation embryos. The occurrence of mitotic
errors is highest during the first three cleavages after fertilization and as a result about three …

Human beings are made of~ 50 trillion cells which arise from serial mitotic divisions of a
single cell-the fertilised egg. Remarkably, the early human embryo is often chromosomally …

STUDY QUESTION What is the prevalence and developmental significance of morphologic
nuclear abnormalities in human preimplantation embryos? SUMMARY ANSWER Nuclear …

Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is
coupled with fast proliferation. ESCs display a constitutively active DNA damage response …

Following in vitro fertilisation (IVF), only about half of normally fertilised human embryos
develop beyond cleavage and morula stages to form a blastocyst in vitro. Although many …

Human embryo development occurs through a process that encompasses reprogramming,
sequential cleavage divisions and mitotic chromosome segregation and embryonic genome …

Whole-chromosome imbalances affect over half of early human embryos and are the
leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis …