Alzheimer's disease (AD) is the major form of dementia in the elderly population. The main
neuropathological changes in AD patients are neuronal death, synaptic alterations, brain …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by progressive memory loss and learning impairment. Dysfunction of amyloid …

The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's
disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue …

The blood-brain barrier (BBB) influences brain levels of amyloid-β (Aβ) by transporting Aβ
out of the brain (efflux) and by the reabsorption of cerebrospinal fluid (CSF) into the blood …

According to the amyloid hypothesis, accumulation of amyloid β‐peptide (Aβ) in the brain is
the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that …

Alzheimer's disease (AD) is characterized by deposition and accumulation of amyloid-β (Aβ)
and its corresponding plaques within the brain. Although much debate exists whether these …

Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ)
aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer's …

Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The
physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its …

Mutations in the amyloid precursor protein (APP) gene are associated with altered
production and deposition of amyloid beta (Aβ) peptide in the Alzheimer's disease (AD) …

Previous reports showed that brain Aβ amyloidosis can be induced in animal models by
exogenous administration of pre-formed aggregates. To date, only intra-peritoneal and intra …