Development of a novel zein-derived peptide: in vitro assays, and 2D-and 3D-cell models

PA Trinidad Calderón - 2022 - repositorio.tec.mx
Maize is the most consumed staple crop worldwide. Its composition, abundant in prolamins
corresponding to α-zein, represents an opportunity for the search of bioactive candidates …

nurP28, a new-to-nature zein-derived peptide, enhances the therapeutic effect of docetaxel in breast cancer monolayers and spheroids

PA Trinidad-Calderón, LM López-Castillo… - Molecules, 2022 - mdpi.com
The development of novel cancer therapeutic strategies has garnered increasing interest in
cancer research. Among the therapeutic choices, chemosensitizers have shown exciting …

In silico analysis and in vitro characterization of the bioactive profile of three novel peptides identified from 19 kDa α-zein sequences of maize

JL Díaz-Gómez, I Neundorf, LM López-Castillo… - Molecules, 2020 - mdpi.com
In this study, we characterized three novel peptides derived from the 19 kDa α-zein, and
determined their bioactive profile in vitro and developed a structural model in silico. The …

Novel α-zein peptide fractions with in vitro cytotoxic activity against hepatocarcinoma

JL Díaz-Gómez, LM López-Castillo… - Food and Bioproducts …, 2022 - Elsevier
Hepatocarcinoma is one of the main causes of cancer-related deaths worldwide. Maize
peptides have emerged a novel group of anticancer peptides to investigate. In this study, we …

Novel a-zein peptide fractions with in vitro cytotoxic activity against hepatocarcinoma.

JL Díaz-Gómez, LM López-Castillo, S Garcia-Lara… - 2022 - cabidigitallibrary.org
Hepatocarcinoma is one of the main causes of cancer-related deaths worldwide. Maize
peptides have emerged a novel group of anticancer peptides to investigate. In this study, we …

PEP-010, a cell penetrating & interfering peptide as a new therapeutic approach in breast cancer

S Lebel-Binay, F Nemati, L Dominguez-Berrocal… - Cancer Research, 2018 - AACR
Introduction. The interaction between intracellular caspase-9 and PP2A proteins is critical to
apoptosis. We designed PEP-010, a Cell Penetrating & Interfering Peptide, which …

Characterization of the protein and peptide of excipient zein by the multi-enzyme digestion coupled with nano-LC-MS/MS

M Li, H Zheng, M Lin, W Zhu, J Zhang - Food chemistry, 2020 - Elsevier
Zein, a class of prolamine proteins extracted from maize, is extensively used in the food and
pharmaceutical industries. Characterization of its components is essential for quality control …

Antioxidant activity of zein hydrolysates from Zea species and their cytotoxic effects in a hepatic cell culture

JL Díaz-Gómez, M Ortíz-Martínez, O Aguilar… - Molecules, 2018 - mdpi.com
In recent years, food proteins with bioactivity have been studied for cancer treatment. Zein
peptides have shown an important set of bioactivities. This work compares the cytotoxic …

Zein—A plant protein as a promising biopolymer for biomedical applications: A perspective

AR Reshma, MR Rekha - Journal of …, 2024 - systems.enpress-publisher.com
Recent technological advances in the fields of biomaterials and tissue engineering have
spurred interest in biopolymers for various biomedical applications. The advantage of …

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

MS Amin, B Yu, D Wu, Y Lu, W Wu, J Wang, Y Zhang… - Foods, 2024 - mdpi.com
Dietary protein supplementation has emerged as a promising strategy in combating
sarcopenia. Furthermore, searching for alternatives of animal proteins has been a hot topic …