Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Necroptosis is a form of cell death that can be observed downstream of death receptor or
pattern recognition receptor signaling under certain cellular contexts, or in response to some …

Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation …

RIPK1 and RIPK3 (receptor-interacting serine/threonine protein kinases 1/3) interact by
virtue of their RIP homotypic interaction motifs to mediate a form of cell death called …

Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing
intracellular components that can trigger an innate immune response. Toll-like receptor 3 …

Inflammation is a healthy response to infection or danger and should be rapid, specific and
terminated once the threat has passed. Inflammatory diseases, where this regulation fails …

Recent advances have identified a signaling cascade involving receptor interacting protein
kinase 1 (RIPK1), RIPK3 and the pseudokinase mixed lineage kinase domain-like (MLKL) …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Necroptosis is a form of programmed cell death that depends on the activation of receptor
interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as tumor necrosis factor …

Many different types of programmed cell death (PCD) have been identified, including
apoptosis and necroptosis. Apoptosis is a type of cell death that is controlled by various …