Simple Summary Hypoxia (reduced oxygen availability) is common in the majority of
tumours, including head and neck cancer, and it occurs due to an imbalance between …

Hypoxia is a common feature in most of the solid tumors including head and neck squamous
cell carcinoma (HNSCC). Hypoxia reflects the imbalance between oxygen consumption by …

Introduction: Tumor hypoxia is a major cause for failure of therapy in patients with inoperable
head and neck cancers. Areas covered: Various anti-hypoxic treatment strategies (eg …

Background: The importance of tumour hypoxia for the outcome of radiotherapy has been
under investigation for decades. Numerous clinical trials modifying the hypoxic …

Conclusion After years of effort, tumor hypoxia continues to represent a therapeutic
challenge in HNSCC. Nonetheless, the prospect of reducing its impact is looking brighter …

Intensity-modulated radiation therapy (IMRT) has revolutionized radiation treatment for head
and neck cancers (HNCs). When compared to the traditional techniques, IMRT has the …

Head and Neck cancer (HNC) is a complex mix of cancers and one of the more common
cancers with a relatively poor prognosis. One of the factors that may assist us in predicting …

Recurrent squamous cell carcinoma of the head and neck (SCCHN) carries a poor
prognosis. Tumor hypoxia (TH) has been implicated as one of many factors contributing to …

It is now well established that most animal solid tumors contain oxygen-deficient hypoxic
cells and that these cells will influence the response of those tumors to radiation. Identifying …

Despite the clear evidence that hypoxia is deleterious for achieving local tumor control and
better survival after radiotherapy, there is no established method for reducing or eliminating …