Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

The potential use of gene therapy to treat human disease increases with the development of
various physical, chemical, and biological methods to deliver genes to mammalian cells …

Chronic nonhealing wounds represent a large clinical problem resulting in severe
disabilities and large healthcare expenditures. Despite the scope of this problem, effective …

Gene therapy is becoming a reality, and it is a particularly attractive approach for wound
healing, because the wound site is often exposed, the treatment and condition should be …

The first approved human gene therapy trial started on September 14, 1990. Researchers at
the US National Institutes of Health removed white blood cells from the body of 4-year-old …

Different therapies that modulate wound repair have been proposed over the last few
decades. This article reviews the two emerging fields of gene and stem cell therapy in …

Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing
impairment; therefore, treatments to improve hemodynamics and increase wound …

The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Gene therapy was traditionally considered a treatment modality for patients with congenital
defects of key metabolic functions or late-stage malignancies. The realization that gene …

Wound repair involves the sequential interaction of various cell types, extracellular matrix
molecules, and soluble mediators. During the past 10 years, much new information on …