Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …
Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer's disease risk
YWA Huang, B Zhou, AM Nabet, M Wernig… - Journal of …, 2019 - Soc Neuroscience
In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …
Vascular ApoE4 impairs behavior by modulating gliovascular function
The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in …
Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in …
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Apolipoprotein E (APOE) genetic variants have been shown to modify Alzheimer's disease
(AD) risk. We previously identified an APOE3 variant (APOE 3-V236E), named APOE3 …
(AD) risk. We previously identified an APOE3 variant (APOE 3-V236E), named APOE3 …
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
M Shinohara, T Kanekiyo, L Yang… - Annals of …, 2016 - Wiley Online Library
Objective Apolipoprotein E (apoE), a major cholesterol carrier in the brain, is associated with
a strong risk for Alzheimer disease. Compared to the risky APOE4 gene allele, the effects of …
a strong risk for Alzheimer disease. Compared to the risky APOE4 gene allele, the effects of …
The role of APOE in cerebrovascular dysfunction
LM Tai, R Thomas, FM Marottoli, KP Koster… - Acta …, 2016 - Springer
The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline
during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other …
during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other …
Genetic restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice
C Lane-Donovan, WM Wong… - Journal of …, 2016 - Soc Neuroscience
Alzheimer's disease (AD) is the most common form of dementia in individuals over the age
of 65 years. The most prevalent genetic risk factor for AD is the ε4 allele of apolipoprotein E …
of 65 years. The most prevalent genetic risk factor for AD is the ε4 allele of apolipoprotein E …
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
Inheritance of the ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor
associated with the sporadic form of Alzheimer's disease (AD), whereas the rare APOE ε2 …
associated with the sporadic form of Alzheimer's disease (AD), whereas the rare APOE ε2 …
APOE4 derived from astrocytes leads to blood–brain barrier impairment
RJ Jackson, JC Meltzer, H Nguyen, C Commins… - Brain, 2022 - academic.oup.com
Apolipoprotein E (ApoE) is a multifaceted secreted molecule synthesized in the CNS by
astrocytes and microglia, and in the periphery largely by the liver. ApoE has been shown to …
astrocytes and microglia, and in the periphery largely by the liver. ApoE has been shown to …
The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
T Nuriel, KY Peng, A Ashok, AA Dillman… - Frontiers in …, 2017 - frontiersin.org
Possession of the ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …