Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity
information to inform the strategy used for the isolation of new bioactive compounds …

Marine natural products (MNPs) have been an important and rich source for antimicrobial
drug discovery and an effective alternative to control drug resistant infections. Herein, we …

Marine sponges harbor diverse microbial communities that represent a significant source of
natural products. In the present study, extracts of 21 sponge-associated bacteria were …

Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …

The drug discovery process can be divided into 4 steps namely: drug target identification,
target validation, lead compounds identification, and optimization (Scheme 1). The aim of …

The deep ocean is the largest habitat for life on Earth, though the microorganisms that
occupy this unique environmental niche remain largely unexplored. Due to the significant …

Marine-derived bacteria are a prolific source of a wide range of structurally diverse natural
products. This review, dedicated to Professor William Fenical, begins by showcasing many …

A high-throughput (HT) paradigm generating LC-MS-UV-ELSD-based natural product
libraries to discover compounds with new bioactivities and or molecular structures is …

The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range
across the Indian and Western Tropical Pacific Oceans and is a prolific producer of …

Bioassay-guided fractionation of extracts from temperate Australian collections of the marine
sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new …