[HTML][HTML] Towards combating antibiotic resistance by exploring the quantitative structure-activity relationship of NDM-1 inhibitors
Abstract The emergence of New Delhi metallo-beta-lactamase-1 (NDM-1) has conferred
enteric bacteria resistance to almost all beta-lactam antibiotics. Its capability of horizontal …
enteric bacteria resistance to almost all beta-lactam antibiotics. Its capability of horizontal …
Applications of machine‐learning methods for the discovery of NDM‐1 inhibitors
C Shi, F Dong, G Zhao, N Zhu, X Lao… - Chemical Biology & …, 2020 - Wiley Online Library
Abstract The emergence of New Delhi metal beta‐lactamase (NDM‐1)‐producing bacteria
and their worldwide spread pose great challenges for the treatment of drug‐resistant …
and their worldwide spread pose great challenges for the treatment of drug‐resistant …
[HTML][HTML] Identification of a potential inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) using in silico and in vitro approaches
New Delhi metallo-β-lactamase-1 (NDM-1), expressed in different Gram-negative bacteria,
is a versatile enzyme capable of hydrolyzing β-lactam rings containing antibiotics such as …
is a versatile enzyme capable of hydrolyzing β-lactam rings containing antibiotics such as …
An in silico approach to identify potential NDM-1 inhibitors to fight multidrug resistant superbugs
S Barman, B Phukan, PS Borah, M Puzari… - Current Drug …, 2019 - ingentaconnect.com
Background: Antibiotic resistance is a global threat and the emergence of Multi-Drug
Resistant (MDR) bacteria compromises the treatment options, limiting the number of …
Resistant (MDR) bacteria compromises the treatment options, limiting the number of …
[PDF][PDF] An in silico approach to discover potential inhibitors against multi-drug resistant bacteria producing New-Delhi metallo-β-Lactamase 1 (NDM-1) enzyme
ABSTRACT New Delhi Metallo-β-lactamase 1 (NDM-1) is a monomeric, plasmid-encoded
enzyme that can hydrolyze β-lactam antibiotics over a wide range. Presence of this enzyme …
enzyme that can hydrolyze β-lactam antibiotics over a wide range. Presence of this enzyme …
Identification of a potential inhibitor for New Delhi metallo-β-lactamase 1 (NDM-1) from FDA approved chemical library-a drug repurposing approach to combat …
Superbugs producing New Delhi metallo-β-lactamase 1 (NDM-1) enzyme is a growing
crisis, that is adversely affecting the global health care system. NDM-1 empowers the …
crisis, that is adversely affecting the global health care system. NDM-1 empowers the …
Machine Learning Models Identify Inhibitors of New Delhi Metallo-β-lactamase
The worldwide spread of the metallo-β-lactamases (MBL), especially New Delhi metallo-β-
lactamase-1 (NDM-1), is threatening the efficacy of β-lactams, which are the most potent and …
lactamase-1 (NDM-1), is threatening the efficacy of β-lactams, which are the most potent and …
[HTML][HTML] New N-alkylated heterocyclic compounds as prospective NDM1 inhibitors: Investigation of in vitro and in silico properties
Y Kaddouri, B Bouchal, F Abrigach, M El Kodadi… - Pharmaceuticals, 2022 - mdpi.com
A new family of pyrazole-based compounds (1–15) was synthesized and characterized
using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C NMR, and …
using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C NMR, and …
[HTML][HTML] Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1)
The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …
In Silico and In Vitro Screening of Natural Compounds as Broad‐Spectrum β‐Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo‐β …
A Vasudevan, DK Kesavan, L Wu, Z Su… - BioMed research …, 2022 - Wiley Online Library
Antibiotic resistance is one of the significant problems globally; there is an increase in
resistance with introducing every new class of antibiotics. Further, this has become one of …
resistance with introducing every new class of antibiotics. Further, this has become one of …