Hypertension increases cardiovascular risk and renal disease in type 1 diabetes mellitus
(T1DM)(1). The normal natriuretic response (pressure natriuresis, PN) that offsets increased …

Key points Type 1 diabetes mellitus increases cardiovascular risk; hypertension amplifies
this risk, while pressure natriuresis regulates long‐term blood pressure. We induced type 1 …

Type 1 diabetes mellitus (T1DM) leads to serious complications including premature
cardiovascular and kidney disease. Hypertension contributes importantly to these adverse …

Dysregulation of renal sodium and water transport proteins in diabetic Zucker rats.
Background Diabetic nephropathy is commonly associated with renal salt and water …

Uncontrolled diabetes mellitus (DM) is associated with copious water and sodium losses.
We hypothesized that the kidney compensates for these losses by increasing the …

Background/Aims: Intravascular volume expansion due to sodium retention is involved in the
pathogenesis of obesity-related hypertension. Institution of high fat diet (HFD) feeding leads …

Acute hypertension in Sprague-Dawley rats (SD) provokes a decrease in renal proximal
tubule (PT) salt and fluid reabsorption, redistribution of apical Na/H exchanger isoform 3 …

Acute arterial hypertension provokes a rapid decrease in proximal tubule (PT) Na+
reabsorption, increasing flow to the macula densa, the signal for tubuloglomerular feedback …

New Findings What is the central question of the study? Chronic glucose feeding
accompanied by glucose injection (ip) causes sustained hyperglycaemia and hypertension …

An increase in blood pressure (BP) due to angiotensin II (ANG II) infusion or other means is
associated with adaptive pressure natriuresis due to reduced sodium reabsorption primarily …