H Dvory-Sobol, N Shaik, C Callebaut… - Current Opinion in HIV …, 2022 - journals.lww.com
Lenacapavir: a first-in-class HIV-1 capsid inhibitor : Current Opinion in HIV and AIDS Lenacapavir: a first-in-class HIV-1 capsid inhibitor : Current Opinion in HIV and AIDS Log in or …
Lenacapavir (Sunlenca®) is a long-acting capsid inhibitor of human immunodeficiency virus type 1 (HIV-1) being developed by Gilead Sciences Inc. It is available as an oral tablet and …
M Desai, G Iyer, RK Dikshit - Indian journal of pharmacology, 2012 - journals.lww.com
Human immunodeficiency virus (HIV) infection is now recognized as a chronic illness. Although the success of highly active antiretroviral therapy is beyond question, several …
SK Gupta, M Berhe, G Crofoot, P Benson… - The Lancet …, 2023 - thelancet.com
Background Antiretroviral agents with novel mechanisms and dosing intervals could expand treatment options for people with HIV. Lenacapavir, an inhibitor of capsid protein that makes …
E De Clercq - Current opinion in pharmacology, 2010 - Elsevier
In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3′-azido-2′, 3′-dideoxythymidine), was described. It was the first of 25 …
E De Clercq - International journal of antimicrobial agents, 2009 - Elsevier
In 2008, 25 years after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of acquired immune deficiency syndrome (AIDS), exactly 25 anti …
More than 20 individual and fixed-dose combinations of antiretrovirals are approved for the treatment of human immunodeficiency virus (HIV) infection. However, owing to the ongoing …
E De Clercq - Expert opinion on emerging drugs, 2005 - Taylor & Francis
There are now exactly 20 anti-HIV drugs licenced (approved) for clinical use, and> 30 anti- HIV compounds under (pre) clinical development. The licenced anti-HIV drugs fall into five …
JA Esté, T Cihlar - Antiviral research, 2010 - Elsevier
Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus …