[HTML][HTML] The immune system as a therapeutic target for Alzheimer's disease

T Zieneldien, J Kim, D Sawmiller, C Cao - Life, 2022 - mdpi.com
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and is the most
common cause of dementia. Furthermore, aging is considered the most critical risk factor for …

Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies

YH Liu, F Zeng, YR Wang, HD Zhou, B Giunta… - Drug Discovery …, 2013 - Elsevier
Highlights•Immunity is closely related to the pathogenesis of AD.•Aging contributes to the
dysregulation of immunity and inflammation which are related to AD.•Modulating the …

[HTML][HTML] Friend, foe or both? Immune activity in Alzheimer's disease

GR Frost, LA Jonas, YM Li - Frontiers in Aging Neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …

Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review

S Mahdiabadi, S Momtazmanesh, G Perry… - Reviews in the …, 2022 - degruyter.com
Abstract Alzheimer's disease (AD), the most common cause of dementia, is characterized by
progressive cognitive and memory impairment ensued from neuronal dysfunction and …

[HTML][HTML] Alzheimer's disease and immunotherapy

J Madeo, M Frieri - Aging and disease, 2013 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a growing health care epidemic. It is the most common cause of
dementia and its incidence is rising. Age, which influences the oxidative and inflammatory …

The role of the immune system in Alzheimer disease: Etiology and treatment

S Jevtic, AS Sengar, MW Salter, JA McLaurin - Ageing research reviews, 2017 - Elsevier
The immune system is now considered a major factor in Alzheimer Disease (AD). This
review seeks to demonstrate how various aspects of the immune system, both in the brain …

[HTML][HTML] The impact of ageing on the CNS immune response in Alzheimer's disease

SEJ Chee, E Solito - Frontiers in Immunology, 2021 - frontiersin.org
Alzheimer's Disease (AD) is a progressive neurodegenerative disease strongly associated
with increasing age. Neuroinflammation and the accumulation of amyloid protein are …

Neuroimmune mechanisms underlying Alzheimer's disease: insights into central and peripheral immune cell crosstalk

Y Liu, Y Tan, Z Zhang, H Li, M Yi, Z Zhang, S Hui… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is a highly life-threatening neurodegenerative disease.
Dysregulation of the immune system plays a critical role in promoting AD, which has …

Immunology meets neuroscience–opportunities for immune intervention in neurodegenerative diseases

MA Lynch, KHG Mills - Brain, behavior, and immunity, 2012 - Elsevier
Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative
diseases but the extent to which the immune system is involved in the pathogenesis of these …

[HTML][HTML] Innate immune activation in Alzheimer's disease

MM Wang, D Miao, XP Cao, L Tan… - Annals of translational …, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is known as the most predominant cause of dementia among the
aged people. Previously, two hallmarks of AD pathology including extracellular amyloid-β …