To thoroughly investigate the uncharted chemical space around the entrance channel of HIV-
1 reverse transcriptase (RT) and to improve the physicochemical properties, we introduced …

For more in-depth exploration of the chemical space around the entrance channel of HIV-1
reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing different …

To further explore the chemical space around the entrance channel of HIV-1 reverse
transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing N-substituted …

To explore the chemical space around the entrance channel of the HIV-1 reverse
transcriptase (RT) binding pocket, we innovatively designed and synthesized a series of …

Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase
inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an indispensable part of
anti-HIV-1 therapy. To discover novel HIV-1 NNRTIs with increased drug resistance profiles …

Since the entrance channel was proposed as a new binding site in non-nucleoside reverse
transcriptase inhibitor binding pocket (NNIBP) of HIV-1 reverse transcriptase (RT) in 2012, a …

This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting
the highly conserved Tyr318 in the HIV-1 non-nucleoside reverse transcriptase inhibitors …

In our previous work, novel 2, 4, 5-trisubstituted thiazole derivatives (TSTs) were
synthesized, and their activities were evaluated against HIV-1 reverse transcriptase. Some …

In this study, a novel series of diarylpyrimidine derivatives with Fsp3‐enriched spirocycles
were designed and synthesized to further explore the chemical space of the hydrophobic …