Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …

Purpose In this review, we highlight the current concepts and discuss some of the current
challenges and future prospects in cancer therapy. We frequently use the example of lung …

Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …

Immunotherapy has become the central pillar of cancer therapy. Immune checkpoint
inhibitors (ICIs), a major category of tumor immunotherapy, reactivate preexisting anticancer …

Immune checkpoint inhibitor therapy has revolutionized the field of cancer immunotherapy.
Even though it has shown a durable response in some solid tumors, several patients do not …

Abstract 'First-generation'immune checkpoint inhibitors targeting Cytotoxic T-Lymphocyte
Antigen 4 (CTLA4) and Programmed death-ligand 1 (PD (L) 1) have undoubtedly …

Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …

Purpose The breakthrough therapy program was established in 2012 to expedite the
development and review of new medicines. We evaluated the times to approval, efficacy …