The immune system is a complex, dynamic, and plastic ecosystem composed of multiple cell
types that constantly sense and interact with their local microenvironment to protect from …

Immune cells are characterized by diversity, specificity, plasticity, and adaptability—
properties that enable them to contribute to homeostasis and respond specifically and …

The immunology field has invested great efforts and ingenuity to characterize the various
immune cell types and elucidate their functions. However, accumulating evidence indicates …

The immune system varies in cell types, states, and locations. The complex networks,
interactions, and responses of immune cells produce diverse cellular ecosystems composed …

The immune system encompasses a large degree of phenotypic diversity and plasticity in its
cell types, and more is to be uncovered. We argue that large, multiomic datasets of single …

The mammalian immune system is tasked with protecting the host against a broad range of
threats. Understanding how immune populations leverage cellular diversity to achieve this …

Single-cell genomics offers powerful tools for studying immune cells, which make it possible
to observe rare and intermediate cell states that cannot be resolved at the population level …

During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …

The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …