Electrochemical synthesis of isoxazolines: Method and mechanism

SDL Holman, AG Wills, NJ Fazakerley… - … A European Journal, 2022 - Wiley Online Library
An electrochemical method for the green and practical synthesis of a broad range of
substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes …

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes

S Hofmann, J Winter, T Prenzel… - …, 2023 - Wiley Online Library
Isoxazol (in) es are widely featured structural motifs in natural products, agrochemicals, and
pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis …

Electrochemical Activation of Nitromethane to Construct Isoxazoline Aldoximes

S Ji, L Zhao, B Miao, M Xue, T Pan… - Angewandte Chemie …, 2023 - Wiley Online Library
Activation of nitromethane to endow new reactivity is an interesting and meaningful but also
challenging topic. Herein, we report an electrochemical activation of nitromethane to serve …

Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

A Prabhakar Kale, P Nikolaienko… - European Journal of …, 2021 - Wiley Online Library
A highly regioselective protocol for the synthesis of isoxazolines through cascade C− O and
C− Br bond formation has been developed. The electrochemical approach uses traceless …

Recent advances in the oxime-participating synthesis of isoxazolines

J Liao, L Ouyang, Q Jin, J Zhang, R Luo - Organic & Biomolecular …, 2020 - pubs.rsc.org
Isoxazoline compounds are used as important intermediates for the synthesis of organic
molecules, which are widely used in the chemical and life science industries. Oxime …

[HTML][HTML] Electrochemical (3+ 2) cyclization between amides and olefins

XA Liang, L Niu, S Wang, A Lei - Chem Catalysis, 2021 - cell.com
Amides and olefins are cheap and readily available industrial materials. Hence, the
synthesis of oxazolines from amides and olefins is significant. Regio-and site-selective …

Electrooxidative Dearomatization to Spiroisoxazolines: Application to Total Synthesis of Xanthoisoxazoline B

D Chen, T He, Y Jin, S Huang - Advanced Synthesis & Catalysis, 2022 - Wiley Online Library
The synthesis of spiroisoxazoline molecules has been developed via anodic oxidative
dearomatization of 4‐methoxybenzyl oximes. The reaction is thought to proceed through 5 …

Synthesis of oxazoline and oxazole derivatives by hypervalent-iodine-mediated oxidative cycloaddition reactions

A Yoshimura, A Saito, MS Yusubov, VV Zhdankin - Synthesis, 2020 - thieme-connect.com
Organohypervalent iodine reagents are widely used for the preparation of various
oxazolines, oxazoles, isoxazolines, and isoxazoles. In the formation of these heterocyclic …

Base‐Promoted [3+ 2]‐Annulation of Oxime Esters and Aldehydes for Rapid Isoxazoline Formation

H Huang, F Li, Z Xu, J Cai, X Ji… - Advanced Synthesis & …, 2017 - Wiley Online Library
Abstract A base‐promoted [3+ 2]‐annulation of ketoxime esters and aldehydes is disclosed
for the facile and rapid synthesis of 3, 5‐disubstituted and 3, 4, 5‐trisubstituted isoxazolines …

Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic KI and Oxone as the terminal oxidant

A Yoshimura, C Zhu, KR Middleton… - Chemical …, 2013 - pubs.rsc.org
Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic
KI and Oxone as the terminal oxidant - Chemical Communications (RSC Publishing) DOI:10.1039/C3CC41164H …