Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases
Small extracellular vesicles (sEVs) are a group of cell-secreted nanovesicles with a diameter
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
Delivery of functional small RNAs via extracellular vesicles in vitro and in vivo
Extracellular vesicles (EVs) are naturally generated nanovesicles which potentially mediate
the intercellular communication and interorgan crosstalk. EVs have recently gained …
the intercellular communication and interorgan crosstalk. EVs have recently gained …
Exosome-mediated small RNA delivery: a novel therapeutic approach for inflammatory lung responses
Exosomes (EXOs) are a type of extracellular nanovesicles released from living cells.
Accumulating evidence suggests that EXOs are involved in the pathogenesis of human …
Accumulating evidence suggests that EXOs are involved in the pathogenesis of human …
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary
illnesses and dysfunctions. Therapeutics have been developed, but they present major …
illnesses and dysfunctions. Therapeutics have been developed, but they present major …
Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages
L De Backer, T Naessens, S De Koker, E Zagato… - Journal of Controlled …, 2015 - Elsevier
The local delivery of small interfering RNA (siRNA) to the lungs may provide a therapeutic
solution to a range of pulmonary disorders. Resident alveolar macrophages (rAM) in the …
solution to a range of pulmonary disorders. Resident alveolar macrophages (rAM) in the …
Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation
Despite lipid nanoparticles'(LNPs) success in the effective and safe delivery of mRNA
vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs …
vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs …
Human umbilical cord mesenchymal stromal cell small extracellular vesicle transfer of microRNA-223-3p to lung epithelial cells attenuates inflammation in acute lung …
J Chen, S Ma, B Luo, H Hao, Y Li, H Yang… - Journal of …, 2023 - Springer
Background Acute lung injury (ALI), manifested as strong pulmonary inflammation and
alveolar epithelial damage, is a life-threatening disease with high morbidity and mortality …
alveolar epithelial damage, is a life-threatening disease with high morbidity and mortality …
Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system
L De Backer, K Braeckmans, MCA Stuart… - Journal of controlled …, 2015 - Elsevier
Inhalation therapy with small interfering RNA (siRNA) is a promising approach in the
treatment of pulmonary disorders. However, clinical translation is severely limited by the lack …
treatment of pulmonary disorders. However, clinical translation is severely limited by the lack …
Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for
pulmonary delivery has not yet fully been established. A major barrier to this therapeutic …
pulmonary delivery has not yet fully been established. A major barrier to this therapeutic …
Cigarette smoke condensate exposure changes RNA content of extracellular vesicles released from small airway epithelial cells
Exposure to environmental tobacco smoke (ETS) is a known risk factor for the development
of chronic lung diseases, cancer, and the exacerbation of viral infections. Extracellular …
of chronic lung diseases, cancer, and the exacerbation of viral infections. Extracellular …