Safety and efficacy of combination SARS-CoV-2 neutralizing monoclonal antibodies amubarvimab plus romlusevimab in nonhospitalized patients with COVID-19

TH Evering, KW Chew, MJ Giganti, C Moser… - Annals of internal …, 2023 - acpjournals.org
Background: Development of safe and effective SARS-CoV-2 therapeutics is a high priority.
Amubarvimab and romlusevimab are noncompeting anti–SARS-CoV-2 monoclonal …

The efficacy and safety of remdesivir alone and in combination with other drugs for the treatment of COVID-19: A systematic review and meta-analysis

C Chen, J Fang, S Chen, MJN Rajaofera, X Li… - BMC Infectious …, 2023 - Springer
Background Remdesivir is considered to be a specific drug for treating coronavirus disease
2019. This systematic review aims to evaluate the clinical efficacy and risk of remdesivir …

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
Background The role of molnupiravir for coronavirus disease 2019 (COVID-19) treatment is
unclear. Methods We conducted a systematic review until 1 November 2022 searching for …

[HTML][HTML] Outpatient convalescent plasma therapy for high-risk patients with early COVID-19: a randomized placebo-controlled trial

A Gharbharan, C Jordans, L Zwaginga… - Clinical Microbiology …, 2023 - Elsevier
Objectives The potential benefit of convalescent plasma (CP) therapy for coronavirus
disease 2019 (COVID-19) is highest when administered early after symptom onset. Our …

COVID-19 and metabolic syndrome

H Dissanayake - Best Practice & Research Clinical Endocrinology & …, 2023 - Elsevier
Convergence of the two pandemics: metabolic syndrome and COVID-19 over last two years
has posed unprecedented challenges to individuals as well as healthcare systems …

[HTML][HTML] Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques

K Rosenke, MC Lewis, F Feldmann, E Bohrnsen… - JCI insight, 2023 - ncbi.nlm.nih.gov
The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable
clinical severity and ability to escape preexisting immunity emphasizes the continued need …

Risk factors for severe infection and mortality in patients with COVID‐19 in patients with multiple myeloma and AL amyloidosis

M Ho, S Zanwar, FK Buadi, S Ailawadhi… - American journal of …, 2023 - Wiley Online Library
Patients with multiple myeloma (MM) have a lower efficacy from COVID‐19 vaccination and
a high rate of mortality from COVID‐19 in hospitalized patients. However, the overall rate …

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo

TY Taha, RK Suryawanshi, IP Chen, GJ Correy… - PLoS …, 2023 - journals.plos.org
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains
limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP …

Efficacy and safety of molnupiravir treatment for COVID-19: a systematic review and meta-analysis of randomized controlled trials

F Tian, Q Feng, Z Chen - International Journal of Antimicrobial Agents, 2023 - Elsevier
Introduction There are currently some differences in the research results of molnupiravir.
This study aimed to evaluate the efficacy and safety of molnupiravir in the treatment of …

Efficacy and safety of Molnupiravir in COVID-19 patients: A systematic review

KR Mali, M Eerike, GM Raj, D Bisoi… - Irish Journal of Medical …, 2023 - Springer
Background Molnupiravir is an oral antiviral drug that received Emergency Use
Authorization in three countries for the treatment of mild COVID-19. The aim of this …