The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor
tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary …

Many naturally occurring protein assemblies have dynamic structures that allow them to
perform specialized functions. For example, clathrin coats adopt a wide variety of …

蛋白质是各类生命活动不可缺少的承担者, 其序列决定了折叠后的三维结构和功能.
这些具有特定功能的蛋白质在生物医学等多个领域具有重要的应用价值. 计算蛋白质设计可以 …

Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC)
maintenance and megakaryocyte differentiation. Here, we report the 3.4 Aresolution …

Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical
Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors …

Enhancing the efficacy of cytokine-based therapies by systematically tuning how an agonist
associates its receptor is emerging as a powerful new concept in drug discovery. De novo …

Proteins are essential to life as they carry out a great variety of biological functions. Protein
sequences determine their three-dimensional structures, and therefore physiological …

Fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine kinase that plays a major
role in developmental processes and metabolism. The dysregulation of FGFR1 through …

Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation
properties that are responsible for disease emergence, therapy failure, and recurrence in …

Transmembrane (TM) domains as simple as a single span can perform complex biological
functions using entirely lipid-embedded chemical features. Computational design has …