The paired-like homeobox transcription factor LEUTX is expressed in human
preimplantation embryos between the 4-and 8-cell stages, and then silenced in somatic …

The mortality of preimplantation embryos is positively correlated with maternal age.
However, the underlying mechanism for the poor quality of embryos remains unclear. Here …

Human pluripotent stem cells (hPSCs) are currently used in clinical applications such as
cardiac regenerative therapy, studying disease models, and drug screening for heart failure …

Background Recent studies uncovered pervasive transcription and translation of thousands
of noncanonical open reading frames (nORFs) outside of annotated genes. The contribution …

Background Despite growing evidence suggesting age‐related molecular changes in
gametes, the impact of paternal age on clinical outcomes during infertility treatments has not …

Numerous reference genes for use with quantitative reverse transcription polymerase chain
reaction (RT-qPCR) have been used for oocytes, eggs, and preimplantation embryos …

Abstract Poly (ADP‐ribosyl) ation (PARylation) is an important post‐translational
modification of proteins that involves the transfer of ADP‐ribose moieties, and plays …

Single-cell multi-omics technologies have thrived in recent years. The combined studies of
different modalities in single cells have enabled comprehensive insights into the complex …

Embryos contain a large number of lipid droplets, and lipid metabolism is gradually activated
during embryonic development to provide energy. However, the regulatory mechanisms …

Mammalian kidneys maintain fluid homeostasis through the cellular activity of nephrons and
the conjoined collecting system. Each epithelial network originates from distinct progenitor …