Doxorubicin (DOX) is an effective anthracycline anti-neoplastic agent used for the treatment
of hematological and solid tumors. Advancements in cancer treatment over several decades …

Over the last decade, endoplasmic reticulum (ER) stress has emerged as an important
mechanism involved in the development of cardiac diseases including ischemia, dilated …

Nicotinamide adenine dinucleotide (NAD) is a hydride carrier involved in redox reactions in
metabolism. Additionally, NAD+ is a substrate of enzymes that mediate vital NAD+ …

Sirtuin (SRT) is one of nicotinamide adenine dinucleotide (NAD)-dependent protein
deacetylases being highly homologous to yeast silencing information regulator 2 (Sir2). In …

Adipose tissue is an important storage unit of the energy in human body. It is distributed as
fat in the body and one of its locations is inside the bone cavity. The bone marrow adipose …

Sirtuins are protein deacylases involved in a variety of cellular pathways. Furthermore, they
contribute to the effects of Caloric Restriction (CR), the reduction of calorie intake which …

This study investigates the in vivo effect of nicotinamide riboside (NR), a nicotinamide
adenine dinucleotide (NAD) precursor, on the NAD metabolome of mouse tissues. In order …

Objective: In this study, we aimed to analyze the expression levels of specific genes that may
contribute to the pathogenesis of multiple sclerosis (MS) in patients and explore the …

KZT weisen nur selten genomische Mutationen auf, weswegen eine gestörte Epigenetik als
Ursache für die Entartung der Keimzellen vermutet wird. Die Epigenetik ist die Regulierung …

Cardiovascular diseases (CVD) are a leading cause of mortality in the United States.
Atherosclerosis, marked by cholesterol buildup in arterial walls, significantly increases the …