The mortality of preimplantation embryos is positively correlated with maternal age.
However, the underlying mechanism for the poor quality of embryos remains unclear. Here …

Previous studies have shown sleep deprivation has an impact on several aspects of health
and disease. Sleep deprivation suppresses melatonin production and excessive HPA …

Well-organized mitochondrial functions and dynamics are critical for early embryonic
development and are operated via a large number of mitochondria-related genes (MtGs) …

The mean age of women seeking infertility treatment has gradually increased over recent
years. This has coincided with the emergence of in vitro maturation (IVM), a method used in …

Some studies have been conducted to explore the influence of growth hormone (GH) on
oocytes in in vitro maturation (IVM); however, previous studies reporting showed different …

In brief Post-ovulatory aging (POA) results in a decline in oocyte quality and embryonic
developmental capacity although the underlying mechanisms remain elusive. This study …

Thyroid hormones are regarded as the major controllers of metabolic rate and oxygen
consumption in mammals. Although it has been demonstrated that thyroid hormone …

STUDY QUESTION Does mitochondrial deficiency affect human embryonic preimplantation
development? SUMMARY ANSWER The presence of a pathogenic mitochondrial variant …

Introduction Fetal hypoxia has long-term effects on postnatal reproductive functions and the
mitochondrial impairments of ovarian granulosa cells may be one of the causes. Melatonin …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …