The effect of cerium dioxide nanoparticles on the viability of hippocampal neurons in Alzheimer's disease modeling

VV Hanzha, NM Rozumna, YV Kravenska… - Frontiers in Cellular …, 2023 - frontiersin.org
The possibilities of using nanoparticle materials based on cerium dioxide (CNPs) are
exciting since they are low toxic and have specific redox, antiradical properties. It can be …

Cerium oxide nanoparticles trigger neuronal survival in a human Alzheimer disease model by modulating BDNF pathway

B D'Angelo, S Santucci, E Benedetti… - Current …, 2009 - ingentaconnect.com
In engineering and materials science, nanotechnology has made significant advances in the
reduction of free radical damage. Despite such advances, there has been little application to …

The Antioxidant Activity of Cerium Oxide Nanoparticles is Size Dependant and Blocks Aβ1‐42‐Induced Free Radical Production and Neurotoxicity

N Singh, E Amateis, JE Mahaney, K Meehan… - 2008 - Wiley Online Library
We have demonstrated that a single 10 nM dose of cerium oxide nanoparticles (CeONP)
with an average size of 10 nm, extends the lifespan & preserves neuronal function in brain …

Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety

BA Rzigalinski, CS Carfagna… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Cerium oxide nanoparticles have widespread use in the materials industry, and have
recently come into consideration for biomedical use due to their potent regenerative …

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

JM Dowding, W Song, K Bossy, A Karakoti… - Cell Death & …, 2014 - nature.com
Evidence indicates that nitrosative stress and mitochondrial dysfunction participate in the
pathogenesis of Alzheimer's disease (AD). Amyloid beta (Aβ) and peroxynitrite induce …

Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer's Disease

Y Hu, H Guo, S Cheng, J Sun, J Du, X Liu… - International Journal …, 2023 - Taylor & Francis
Background Oxidative stress induced reactive oxygen species (ROS) and aggregation of
amyloid β (Aβ) in the nervous system are significant contributors to Alzheimer's disease …

Investigation of therapeutic potential of cerium oxide nanoparticles in Alzheimer's disease using transgenic Drosophila

V Sundararajan, GD Venkatasubbu, S Sheik Mohideen - 3 Biotech, 2021 - Springer
In the current study, the therapeutic potential of cerium oxide nanoparticles (nCeO 2) was
investigated in a human tau (htau) model of Alzheimer's disease (AD), using Drosophila …

Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease

B Zhang, Y Zhao, K Guo, H Tian… - Bioengineering & …, 2023 - Wiley Online Library
Prevention and early intervention are the current focus of treatment for Alzheimer's disease
(AD). An increase in reactive oxygen species (ROS) is a feature of the early stages of AD …

Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

A Cimini, B D'Angelo, S Das, R Gentile, E Benedetti… - Acta biomaterialia, 2012 - Elsevier
Oxidative stress has been found to be associated with the progression of neurodegenerative
diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium …

Europium-doped cerium oxide nanoparticles for microglial amyloid beta clearance and homeostasis

J Machhi, P Yeapuri, M Markovic, M Patel… - ACS chemical …, 2022 - ACS Publications
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Pathologically,
the disease is characterized by the deposition of amyloid beta (Aβ) plaques and the …