Mammalian kidneys maintain fluid homeostasis through the cellular activity of nephrons and
the conjoined collecting system. Each epithelial network originates from distinct progenitor …

The kidney has a very limited capacity to repair. Defining cellular differentiation during
development therefore could aid the understanding of homeostatic and maladaptive …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

Background We reasoned that unraveling the dynamic changes in accessibility of genomic
regulatory elements and gene expression at single-cell resolution will inform the basic …

Changing gene expression patterns is the essential driver of developmental processes.
Growth factors, micro-RNAs, long intergenic noncoding RNAs, and epigenetic marks, such …

The human kidney is a complex organ composed of specialized cell types. To better define
this cellular complexity, we profiled the individual transcriptomes of 22,469 normal human …

Background Research on spatiotemporal gene landscape can provide insights into the
spatial characteristics of human kidney development and facilitate kidney organoid …

A key limitations to understand kidney function and disease development has been that
specific cell types responsible for specific homeostatic kidney function or disease …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …