Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment

VS Urban, A Cegledi, G Mikala - Geroscience, 2023 - Springer
Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a
disease of older adults (the median age at diagnosis is 70 years). The slow progression from …

Diagnostic and therapeutic challenges in the management of intermediate and frail elderly multiple myeloma patients

F Bonello, M Boccadoro, A Larocca - Cancers, 2020 - mdpi.com
Simple Summary Choosing the optimal therapy for elderly patients with multiple myeloma
(MM) poses a difficult challenge for clinicians. Older patients are an extremely …

Myeloma in elderly patients: when less is more and more is more

A Rosko, S Giralt, MV Mateos… - American Society of …, 2017 - ascopubs.org
Multiple myeloma is a plasma cell malignancy that occurs among older adults and accounts
for 15% of all hematologic malignancies in the United States. Thirty-five percent of patients …

Multiple myeloma in elderly patients: presenting features and outcome

P Rodon, C Linassier, JB Gauvain… - European journal of …, 2001 - Wiley Online Library
Few studies have been performed regarding multiple myeloma (MM) in elderly patients. We
report a retrospective series of 130 unselected patients with MM aged 75 yr or more at …

Challenges and strategies in the management of multiple myeloma in the elderly population

S Zanwar, JP Abeykoon, P Kapoor - Current Hematologic Malignancy …, 2019 - Springer
Abstract Purpose of Review Approximately one half of the patient-population in multiple
myeloma (MM) is> 70 years at diagnosis. Despite notable strides in the management and …

The pharmacologic management of multiple myeloma in older adults

JL Dempsey, A Johns, AE Rosko… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Multiple myeloma is a disease predominately affecting older adults. Pivotal to
treating older adults is understanding their physiologic differences compared to younger …

Management of newly diagnosed elderly multiple myeloma patients

C Antoine-Pepeljugoski, MJ Braunstein - Current Oncology Reports, 2019 - Springer
Abstract Purpose of Review Given the median age at diagnosis of 69, multiple myeloma
(MM) is commonly identified among elderly individuals. Over-treatment of the frail may lead …

Multiple myeloma in the elderly.

M Gautier, HJ Cohen - Journal of the American Geriatrics Society, 1994 - europepmc.org
While multiple myeloma is an incurable disease for nearly all patients, current chemotherapy
and supportive care can result in significant disease control and improved duration of …

Multiple myeloma in the older adult: better prospects, more challenges

TM Wildes, A Rosko, SA Tuchman - Journal of clinical oncology, 2014 - ascopubs.org
Purpose Multiple myeloma (MM) is disproportionately diagnosed in older adults; with the
aging of the population, the number of older adults diagnosed with MM will increase by …

Multiple myeloma in the very old: an IASIA conference report

SA Tuchman, GR Shapiro, WB Ershler… - Journal of the …, 2014 - academic.oup.com
Multiple myeloma (MM) in patients aged greater than 80 years poses an increasingly
common challenge for oncology providers. A multidisciplinary workshop was held in which …