Switching of newly synthesized linker-based derivatives of non-steroidal anti-inflammatory drugs toward anti-inflammatory and anticancer activity
A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were
designed and synthesized. All the compounds were well characterized with the help of …
designed and synthesized. All the compounds were well characterized with the help of …
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study
AM Alaa, KEH ElTahir, YA Asiri - European journal of medicinal chemistry, 2011 - Elsevier
A group of cyclic imides (1–13) was designed for evaluation as selective COX-2 inhibitors
and investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat …
and investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat …
Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or …
MT El Sayed, MAMS El-Sharief, ES Zarie, NM Morsy… - Bioorganic …, 2018 - Elsevier
Inflammation is a fundamental physiological process that is essential for survival of human
being but at the same time is one of the major causes of human morbidity and mortality. In …
being but at the same time is one of the major causes of human morbidity and mortality. In …
Dual Anti-Inflammatory and Anticancer Activity of Novel 1, 5-Diaryl Pyrazole Derivatives: Molecular Modeling, Synthesis, In Vitro Activity, and Dynamics Study
P Deivasigamani, SME Rubavathy, N Jayasankar… - Biomedicines, 2024 - mdpi.com
A series of novel 1, 5-diaryl pyrazole derivatives targeting the COX enzyme were designed
by combined ligand and structure-based approach. The designed molecules were then …
by combined ligand and structure-based approach. The designed molecules were then …
Novel 1, 3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and …
AMM Shaker, MI Shahin, AM AboulMagd… - Bioorganic …, 2022 - Elsevier
Three series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were
synthesized, characterized by several spectroscopic techniques, and investigated as …
synthesized, characterized by several spectroscopic techniques, and investigated as …
Arylidene analogues as selective COX-2 inhibitors: synthesis, characterization, in silico and in vitro studies
DL Namera, SS Thakkar, P Thakor… - Journal of …, 2021 - Taylor & Francis
Pyrazole derivatives are known to be as non-steroidal anti-inflammatory drugs (NSAID).
Celecoxib is the pioneer sulfonamide being pyrazole derivative COX-2 inhibitors, which …
Celecoxib is the pioneer sulfonamide being pyrazole derivative COX-2 inhibitors, which …
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2, 5-dione derivatives as multitarget anti-inflammatory agents
In recent years, drug discovery paradigm has been shifted from conventional single target
inhibition toward multitarget design concept. In current research, we have reported …
inhibition toward multitarget design concept. In current research, we have reported …
Targeting inflammation through inhibition of COX-2 by substituted 4-thiazolidinone analogues: in-vitro, in-vivo and in-silico studies
The prolonged or chronic use of anti-inflammatory agents that are being used clinically is
highly unsafe. This flaw or disadvantage has motivated scientists to create new heterocyclic …
highly unsafe. This flaw or disadvantage has motivated scientists to create new heterocyclic …
Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX
Y Huang, B Zhang, J Li, H Liu, Y Zhang, Z Yang… - European Journal of …, 2019 - Elsevier
In this work, a series of novel indole-2-amide compounds were designed, synthesized,
characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b …
characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b …
Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti …
EA Ahmed, MFA Mohamed, OA Omran - RSC advances, 2022 - pubs.rsc.org
Novel quinoxaline derivatives (2a–d, 3, 4a, 4b and 5–15) have been synthesized via the
reaction of 4-methyl-3-oxo-3, 4-dihydroquinoxaline-2-carbohydrazide (1) with different …
reaction of 4-methyl-3-oxo-3, 4-dihydroquinoxaline-2-carbohydrazide (1) with different …