Background and aims Gout is a chronic self-limiting inflammatory arthritis. An increase in
metallothionein-1 (MT-1) has been reported in rheumatoid arthritis and osteoarthritis, and it …

Backgrounds OA (Osteoarthritis) is a predominant degenerative disease, characterized by
the synovial inflammation and cartilage destruction. The pathogenic mechanisms remain …

Introduction Ankylosing spondylitis (AS) is a common form of chronic inflammatory rheumatic
disease. Metallothionein-1 (MT-1) has been known to play an immunosuppressive role in …

Abstract Introduction Metallothionein (MT) isoforms I+ II are polypeptides with potent
antioxidative and anti-inflammatory properties. In healthy kidneys, MT-I+ II have been …

It is now well accepted that an imbalance between the Th17 and regulatory T‐cell responses
is closely associated with the development of rheumatoid arthritis (RA). However, the …

The purpose of this study was to investigate the role of pentraxin 3 (PTX3), a pivotal
component of the innate immune system, in gout. Levels of PTX3 and IL-1β in human …

objective The roles of TLRs and their signal pathway in gouty arthritis (GA) were explored.
Methods TLR2 and TLR4 mRNA was measured using real-time quantitative polymerase …

Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate
(MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an …

Background Soluble urate leads to a pro-inflammatory phenotype in human monocytes
characterized by increased production of IL-1β and downregulation of IL-1 receptor …

Background Gout is an inflammatory arthritis resulting from precipitation of monosodium
urate (MSU) crystals in joints and surrounding tissues. However, the mechanism underlying …