[HTML][HTML] The role of structural biology in the design of sirtuin activators
Sirtuins are NAD+-dependent protein lysine deacylases and mono-ADP-ribosylases whose
activity regulates different pathways, including DNA damage repair, cell survival and …
activity regulates different pathways, including DNA damage repair, cell survival and …
Sirtuin modulators: past, present, and future perspectives
F Fiorentino, N Mautone, M Menna… - Future Medicinal …, 2022 - Taylor & Francis
Sirtuins are NAD+-dependent protein lysine deacylase and mono-ADP ribosylases present
in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in …
in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in …
Structures, substrates, and regulators of mammalian Sirtuins–opportunities and challenges for drug development
S Moniot, M Weyand, C Steegborn - Frontiers in pharmacology, 2012 - frontiersin.org
Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress
responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1–7, which …
responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1–7, which …
Current Trends in Sirtuin Activator and Inhibitor Development
Sirtuins are NAD+-dependent protein deacylases and key metabolic regulators, coupling the
cellular energy state with selective lysine deacylation to regulate many downstream cellular …
cellular energy state with selective lysine deacylation to regulate many downstream cellular …
Human sirtuin regulators: the “success” stories
The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl
modifications from lysine residues in various cellular targets including histones, transcription …
modifications from lysine residues in various cellular targets including histones, transcription …
New assays and approaches for discovery and design of Sirtuin modulators
M Schutkowski, F Fischer, C Roessler… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Sirtuins are an evolutionarily conserved family of NAD+-dependent protein
lysine deacylases. In mammals, 7 Sirtuin isoforms control various functions in metabolism …
lysine deacylases. In mammals, 7 Sirtuin isoforms control various functions in metabolism …
Identification and characterization of novel sirtuin inhibitor scaffolds
BD Sanders, B Jackson, M Brent, AM Taylor… - Bioorganic & medicinal …, 2009 - Elsevier
The sirtuin proteins are broadly conserved NAD+-dependent deacetylases that are
implicated in diverse biological processes including DNA recombination and repair …
implicated in diverse biological processes including DNA recombination and repair …
[HTML][HTML] Structure-based development of novel sirtuin inhibitors
C Schlicker, G Boanca, M Lakshminarasimhan… - Aging (Albany …, 2011 - ncbi.nlm.nih.gov
Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress
responses, and aging processes. Mammalia possess seven Sirtuin isoforms, Sirt1-7, which …
responses, and aging processes. Mammalia possess seven Sirtuin isoforms, Sirt1-7, which …
Sirtuin activators and inhibitors: Promises, achievements, and challenges
H Dai, DA Sinclair, JL Ellis, C Steegborn - Pharmacology & therapeutics, 2018 - Elsevier
The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
Sirtuins in neurodegenerative diseases: a biological-chemical perspective
A Raghavan, ZA Shah - Neurodegenerative Diseases, 2011 - karger.com
Sirtuins, commonly known as NAD+-dependent class III histone deacetylase enzymes, have
been extensively studied to evaluate their potential role in different disease states. Based on …
been extensively studied to evaluate their potential role in different disease states. Based on …