The paired-like homeobox transcription factor LEUTX is expressed in human
preimplantation embryos between the 4-and 8-cell stages, and then silenced in somatic …

Recently, human PAIRED-LIKE homeobox transcription factor (TF) genes were discovered
whose expression is limited to the period of embryo genome activation up to the 8-cell stage …

Leucine twenty homeobox (LEUTX) is a paired (PRD)-like homeobox gene that is expressed
almost exclusively in human embryos during preimplantation development. We previously …

Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …

Emerging evidence highlights the regulatory role of paired-like (PRD-like) homeobox
transcription factors (TFs) in embryonic genome activation (EGA). However, the majority of …

During the human oocyte-to-embryo transition, the fertilized oocyte undergoes final
maturation and the embryo genome is gradually activated during the first three cell divisions …

HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although
HUWE1 is known to promote degradation of the tumor suppressor p53, given a growing list …

Transcriptional program that drives human preimplantation development is largely unknown.
Here, by using single-cell RNA sequencing of 348 oocytes, zygotes and single blastomeres …

The LIM homeobox 2 transcription factor Lhx2 is known to control crucial aspects of neural
development in various species. However, its function in human neural development is still …

Abstract Eutherian Totipotent Cell Homeobox (ETCHbox) genes are mammalian-specific
PRD-class homeobox genes with conserved expression in the preimplantation embryo but …