ABSTRACT I provide a narrative of the path I took to discover the membrane receptors that
mediate leukocyte adhesion, now known as β2 integrins or CD11/CD18. We followed this …

Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. 1 With
their extracellular head region, most integrins bind extracellular matrix (ECM) glycoproteins …

Publisher Summary Integrin research is rapidly evolving. Anti-platelet agents are in the clinic
and discovery efforts are ranging across a spectrum of opportunities for the treatment of …

Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular
matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide …

Integrins provide cells with critical means of communication with their microenvironments. By
linking events at the cell surface to a dynamic cytoskeleton-signaling complex, integrins …

Integrins are a structurally elaborate family of adhesion molecules that transmit signals bi-
directionally across the plasma membrane by undergoing large-scale structural …

Initially linked to the pathogenesis of inflammatory and hematologic diseases, integrins have
become validated drug targets with the approval of five drugs. Moreover, there are several …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Integrins are dynamic cell-surface receptors that provide a physical link between the
extracellular matrix and the cell cytoskeleton. The interaction of integrins with extracellular …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …