Metabolism-based cardiomyocytes production for regenerative therapy

TC Umei, S Tohyama, K Fukuda - Journal of Molecular and Cellular …, 2023 - Elsevier
Human pluripotent stem cells (hPSCs) are currently used in clinical applications such as
cardiac regenerative therapy, studying disease models, and drug screening for heart failure …

Metabolism in Human Pluripotent Stem Cells and Cardiomyocytes for Regenerative Therapy

TC Umei, S Tohyama - The Keio journal of medicine, 2022 - jstage.jst.go.jp
Pluripotent stem cells (PSCs), which include embryonic stem cells and induced pluripotent
stem cells, have the potential for unlimited self-renewal and proliferation and the ability to …

[HTML][HTML] Metabolic environment in vivo as a blueprint for differentiation and maturation of human stem cell-derived cardiomyocytes

RH Slaats, V Schwach, R Passier - … Acta (BBA)-Molecular Basis of Disease, 2020 - Elsevier
Patient-derived human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are
increasingly being used for disease modeling, drug screening and regenerative medicine …

Metabolic Remodeling during Early Cardiac Lineage Specification of Pluripotent Stem Cells

SN Bobori, Y Zhu, A Saarinen, AJ Liuzzo, CDL Folmes - Metabolites, 2023 - mdpi.com
Growing evidence indicates that metabolites and energy metabolism play an active rather
than consequential role in regulating cellular fate. Cardiac development requires dramatic …

Maturation of pluripotent stem cell-derived cardiomyocytes: a critical step for drug development and cell therapy

SH Tan, L Ye - Journal of cardiovascular translational research, 2018 - Springer
Cardiomyocytes derived from human pluripotent stem cells (hPSCs) are emerging as an
invaluable alternative to primarily sourced cardiomyocytes. The potentially unlimited number …

Maturation of human pluripotent stem cell derived cardiomyocytes in vitro and in vivo

MJ Gomez-Garcia, E Quesnel, R Al-Attar… - Seminars in cell & …, 2021 - Elsevier
Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) represent an
inexhaustible cell source for in vitro disease modeling, drug discovery and toxicity …

Longitudinal metabolic profiling of cardiomyocytes derived from human-induced pluripotent stem cells

MM Bekhite, A González Delgado, F Menz… - Basic Research in …, 2020 - Springer
Human-induced pluripotent stem cells (h-iPSCs) are a unique in vitro model for
cardiovascular research. To realize the potential applications of h-iPSCs-derived …

Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes

S Tanosaki, S Tohyama, Y Kishino, J Fujita… - Inflammation and …, 2021 - Springer
Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug
discovery, and disease modeling. While several protocols for differentiating somatic cells …

Human cardiomyocyte generation from pluripotent stem cells: A state-of-art

M Talkhabi, N Aghdami, H Baharvand - Life sciences, 2016 - Elsevier
The human heart is considered a non-regenerative organ. Worldwide, cardiovascular
diseases continue to be the leading cause of death. Despite advances in cardiac treatment …

The present state and future perspectives of cardiac regenerative therapy using human pluripotent stem cells

Y Soma, Y Morita, Y Kishino, H Kanazawa… - Frontiers in …, 2021 - frontiersin.org
The number of patients with heart failure (HF) is increasing with aging in our society
worldwide. Patients with HF who are resistant to medication and device therapy are …