[HTML][HTML] Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid

S D'Antoni, S Schiavi, V Buzzelli, S Giuffrida, A Feo… - …, 2023 - Springer
Rationale Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized
by impaired social interaction and restricted/stereotyped behavior. Prenatal exposure to …

[HTML][HTML] Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of …

F Peralta, C Fuentealba… - Molecular Medicine …, 2016 - spandidos-publications.com
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder
characterized by deficits in social communication and social interaction, and repetitive and …

Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test

J Lenart, J Augustyniak, JW Lazarewicz, E Zieminska - Toxicology, 2020 - Elsevier
Autism spectrum disorders (ASD) include neurodevelopmental disorders in which
behavioral deficits can result from neuronal imbalance of excitation to inhibition (E/I) in the …

[HTML][HTML] Effects of (S)-3, 4-DCPG, an mGlu8 receptor agonist, on hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in prenatal valproic …

P Gholipour, Z Ebrahimi, R Mohammadkhani… - Scientific Reports, 2024 - nature.com
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition characterized
by social interaction deficits, communication impairments, repetitive behaviors, and sensory …

Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats

F Bertelsen, A Møller, D Folloni, KR Drasbek… - Acta …, 2017 - cambridge.org
ObjectivePrenatal exposure to valproic acid (VPA) enhances the risk for later development
of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system …

Male‐specific alteration in excitatory post‐synaptic development and social interaction in pre‐natal valproic acid exposure model of autism spectrum disorder

KC Kim, P Kim, HS Go, CS Choi, JH Park… - Journal of …, 2013 - Wiley Online Library
Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by
three main behavioral symptoms including social deficits, impaired communication, and …

Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice

DKF Chau, AYT Choi, W Yang, WN Leung… - Behavioural brain …, 2017 - Elsevier
Abstract The etiology of Autism Spectrum Disorder (ASD) remains controversial. Deficits in
social communication are one of the key criteria for ASD diagnosis. Valproic acid (VPA) …

[HTML][HTML] The state of the dopaminergic and glutamatergic systems in the valproic acid mouse model of autism spectrum disorder

A Maisterrena, E Matas, H Mirfendereski, A Balbous… - Biomolecules, 2022 - mdpi.com
Autism Spectrum Disorder (ASD) is a progressive neurodevelopmental disorder mainly
characterized by deficits in social communication and stereotyped behaviors and interests …

[HTML][HTML] Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism

YW Chen, HC Lin, MC Ng, YH Hsiao… - Frontiers in Behavioral …, 2014 - frontiersin.org
Autism-like phenotypes in male valproate (VPA)-exposed offspring have been linked to high
glutamatergic neurotransmission in the thalamic-amygdala pathway. Glial cystine/glutamate …

[HTML][HTML] Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus

RB Silvestrin, V Bambini-Junior, F Galland… - Brain research, 2013 - Elsevier
Autism spectrum disorders (ASD) are characterized by deficits in social interaction,
language and communication impairments and repetitive and stereotyped behaviors, with …