Rational design of a genome‐based insulated system in Escherichia coli facilitates heterologous uricase expression for hyperuricemia treatment

L He, W Tang, L Huang, W Zhou… - Bioengineering & …, 2023 - Wiley Online Library
Hyperuricemia is a prevalent disease worldwide that is characterized by elevated urate
levels in the blood owing to purine metabolic disorders, which can result in gout and …

[HTML][HTML] Engineering Escherichia coli for diagnosis and management of hyperuricemia

G Gencer, C Mancuso, KJ Chua, H Ling… - … in Bioengineering and …, 2023 - frontiersin.org
Uric acid disequilibrium is implicated in chronic hyperuricemia-related diseases. Long-term
monitoring and lowering of serum uric acid levels may be crucial for diagnosis and effective …

[HTML][HTML] Wild-type Escherichia coli Nissle 1917 improves hyperuricemia by anaerobically degrading uric acid and maintaining gut microbiota profile of mice

Y Sun, D Xu, G Zhang, W Wu, Y Ma, W Kong… - Journal of Functional …, 2024 - Elsevier
Hyperuricemia is an important metabolic disease of humans. Limited clinical drugs such as
allopurinol can alleviate hyperuricemia. Wild-type Escherichia coli Nissle 1917 (EcN) has …

Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment

R Zhao, Z Li, Y Sun, W Ge, M Wang, H Liu, L Xun… - Gut …, 2022 - Taylor & Francis
Hyperuricemia is the second most prevalent metabolic disease to human health after
diabetes. Only a few clinical drugs are available, and most of them have serious side effects …

[HTML][HTML] Construction and expression of recombinant uricase‑expressing genetically engineered bacteria and its application in rat model of hyperuricemia

L Cai, Q Li, Y Deng, X Liu, W Du… - … journal of molecular …, 2020 - spandidos-publications.com
At present, the treatment of hyperuricemia is designed primarily to decrease the production
of uric acid using xanthine oxidase inhibitors; however, the therapeutic effect is not …

[HTML][HTML] Amelioration of hyperuricemia by Lactobacillus acidophilus F02 with uric acid-lowering ability via modulation of NLRP3 inflammasome and gut microbiota …

Y Meng, Y Hu, M Wei, K Wang, Y Wang, S Wang… - Journal of Functional …, 2023 - Elsevier
Hyperuricemia is a metabolic disease caused by disturbances in purine metabolism and
imbalances in the formation and excretion of uric acid. It is closely related to the gut …

A widely distributed gene cluster compensates for uricase loss in hominids

Y Liu, JB Jarman, YS Low, HE Augustijn, S Huang… - Cell, 2023 - cell.com
Approximately 15% of US adults have circulating levels of uric acid above its solubility limit,
which is causally linked to the disease gout. In most mammals, uric acid elimination is …

[HTML][HTML] Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

J Cao, Q Liu, H Hao, Y Bu, X Tian, T Wang… - Frontiers in …, 2022 - frontiersin.org
Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an
increased risk of chronic kidney disease and gout. Probiotics have the potential effect of …

Isolation and identification of uric acid-dependent Aciduricibacillus chroicocephali gen. nov., sp. nov. from seagull feces and implications for hyperuricemia treatment

W Liu, F Nan, F Liu, X Yang, Z Li, S Jiang, X Zhang, J Li… - Msphere, 2024 - Am Soc Microbiol
Hyperuricemia has become the second most prevalent metabolic disease after diabetes, but
the limitations of urate-lowering treatment (ULT) drugs and patient nonadherence make ULT …

Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through …

L Ren, S Wang, S Liu, HAC Prasanthi, Y Li, J Cao… - Foods, 2024 - mdpi.com
Hyperuricaemia (HUA) is a disorder of purine metabolism, which manifests itself as an
increase in uric acid production and a decrease in uric acid excretion, as well as a change in …