Exploring the long-term tissue accumulation and excretion of 3 nm cerium oxide nanoparticles after single dose administration

LM Ernst, L Mondragón, J Ramis, MF Gustà, T Yudina… - Antioxidants, 2023 - mdpi.com
Nanoparticle (NP) pharmacokinetics significantly differ from traditional small molecule
principles. From this emerges the need to create new tools and concepts to harness their full …

Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats

RA Yokel, TC Au, R MacPhail, SS Hardas… - Toxicological …, 2012 - academic.oup.com
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture,
and is being pursued as an antioxidant therapeutic. Our objective is to extend previous …

Bio‐distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice

SM Hirst, A Karakoti, S Singh, W Self… - Environmental …, 2013 - Wiley Online Library
Cerium oxide nanoparticles have oxygen defects in their lattice structure that enables them
to act as a regenerative free radical scavenger in a physiological environment. We …

Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape

RA Yokel, JM Unrine, P Wu, B Wang… - Environmental Science …, 2014 - pubs.rsc.org
A 30 nm ceria was previously shown to be primarily cleared from systemic circulation into
mononuclear phagocyte system organs after its intravenous (IV) administration, where it …

Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose-and route-dependent biokinetics

U Carlander, TP Moto, AA Desalegn… - International Journal …, 2018 - Taylor & Francis
Background Cerium dioxide nanoparticles (nanoceria) are increasingly being used in a
variety of products as catalysts, coatings, and polishing agents. Furthermore, their …

Bioavailability, distribution and clearance of tracheally instilled, gavaged or injected cerium dioxide nanoparticles and ionic cerium

RM Molina, NV Konduru, RJ Jimenez… - Environmental science …, 2014 - pubs.rsc.org
Cerium oxide nanoparticles (NPs) have wide commercial applications. Understanding their
fate in the body is fundamental to toxicological evaluations. We compared bioavailability …

Short-term biodistribution of cerium oxide nanoparticles in mice: focus on brain parenchyma

C Portioli, D Benati, Y Pii, P Bernardi… - Nanoscience and …, 2013 - ingentaconnect.com
Cerium oxide nanoparticles, nanoceria, have been proposed as drug delivery devices and
therapeutic tools also for neurological diseases due to their antioxidant properties and …

Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells

JA Vassie, JM Whitelock, MS Lord - Acta biomaterialia, 2017 - Elsevier
Cerium oxide nanoparticles (nanoceria) are widely reported to be cytocompatible and
modulate intracellular reactive oxygen species (ROS) in a range of different cell types. In this …

Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration

E Casals, M Zeng, M Parra‐Robert, G Fernández‐Varo… - Small, 2020 - Wiley Online Library
Antioxidant nanoparticles have recently gained tremendous attention for their enormous
potential in biomedicine. However, discrepant reports of either medical benefits or toxicity …

Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria

MT Tseng, X Lu, X Duan, SS Hardas, R Sultana… - Toxicology and applied …, 2012 - Elsevier
Beyond the traditional use of ceria as an abrasive, the scope of nanoceria applications now
extends into fuel cell manufacturing, diesel fuel additives, and for therapeutic intervention as …