Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …

Some of the features that characterize the aging process include the gradual accumulation
of damage to cells consequent to prolonged exposure to oxidative and inflammatory events …

To develop successful therapies that prevent or treat neurodegenerative diseases requires
an understanding of the upstream events. Ageing is by far the greatest risk factor for most of …

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Together with the increase in life expectancy the prevalence of neurodegenerative diseases
is rapidly growing. In spite of the scale of the problem, the etiology of most …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The world population is aging rapidly, and increasing lifespan exacerbates the burden of
age-related health issues. On the other hand, premature aging has begun to be a problem …

In this review, we discuss insights gained through the use of stem cell preparations
regarding the modeling of neurological diseases, the need for aging neurons derived from …

Abstract The NIH Summit, Advances in Geroscience: Impact on Health Span and Chronic
Disease, discusses several aspects of cellular degeneration that underlie susceptibility to …