Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling
pathways in immune cells. Notable examples include succinate and itaconate, which have …

Metabolic rewiring underlies the effector functions of macrophages,–, but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …

Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg
effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl …

Metabolic alterations in the microenvironment significantly modulate tumor
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …

The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor
suppressor in a subset of human renal cell carcinomas. Human FH-deficient cancer cells …

The drive to understand how altered cellular metabolism and cancer are linked has caused
a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic …

Background Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor
and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of …

Strict regulation of stem cell metabolism is essential for tissue functions and tumor
suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key …

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in
hereditary and sporadic cancers. Despite recent advances in understanding its role in …