Purpose Exosomes are membrane-derived nano-vesicles upregulated in pathological
conditions like cancer. Therefore, inhibiting their release is a potential strategy for the …

Exosomes are recognized as important mediators of cell‐to‐cell communication, facilitating
carcinogenesis. Although there have been significant advancements in exosome research …

Background and Purpose Extracellular vesicles (EVs) are constitutively shed from cells and
released by various stimuli. Their protein and RNA cargo are modified by the stimulus, and …

Exosomes are nanocarriers that mediate intercellular communication crucial for normal
physiological functions. However, exponentially emerging reports have correlated their …

The long history of discovery and recently encouraging studies of the anti-cancer effect of
aspirin promise a closer step to widely used aspirin-based medication in cancer therapy. To …

The lipid based ESCRT-independent mechanism, which contributes to MVB formation, is
one of the crucial procedures in exosome biogenesis. n-SMase is a key lipid metabolism …

Defective apoptosis signaling and multidrug resistance are major barriers for successful
cancer treatment. To identify drugs capable of targeting treatment-resistant cancer cells, we …

Targeting exosome biogenesis and release may have potential clinical implications for
cancer therapy. Herein, we have optimized a quantitative high throughput screen (qHTS) …

Neutral sphingomyelinase 1 (NSM ase1) mediates caspase‐3 activation and apoptosis.
However, the role of NSM ase1, especially exosome‐borne NSM ase1 in hepatocellular …

Despite their great potential, the nano-sized extracellular vesicles are yet to become
effective delivery systems for poorly water-soluble drugs. Here, we present a novel platform …