A case report of a family with developmental arrest of human prokaryotic stage zygote
T Ma, S Zhou, X Xie, J Chen, J Wang… - Frontiers in Cell and …, 2024 - frontiersin.org
To study the genetic variation leading to the arrest phenotype of pronuclear (PN) zygotes.
We recruited a family characterized by recurrent PN arrest during in vitro fertilization (IVF) …
We recruited a family characterized by recurrent PN arrest during in vitro fertilization (IVF) …
Parameterization of asymmetric sigmoid functions in weighted gene co-expression network analysis
ME Karabekmez, M Yarıcı - Computational Biology and Chemistry, 2024 - Elsevier
In most the biological contexts, examining gene expressions at the genomic level gives
more accurate results than examining genes individually. It can improve understanding of …
more accurate results than examining genes individually. It can improve understanding of …
Neddylation inhibition affects early embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function in mice
M Liu, Z Ding, P Sun, S Zhou, H Wu, L Huo, L Yang… - Theriogenology, 2024 - Elsevier
Post-translational modifications (PTMs) are critical for early development in mice because
early cleavage-stage embryos are characterized by transcriptional inactivity. Neddylation is …
early cleavage-stage embryos are characterized by transcriptional inactivity. Neddylation is …
[PDF][PDF] RZIMM-SCRNA: A REGULARIZED ZERO-INFLATED MIXTURE MODEL FRAMEWORK FOR SINGLE-CELL RNA-SEQ DATA
D CANOLL, J HU - THE ANNALS, 2024 - imstat.org
Applications of single-cell RNA sequencing in various biomedical research areas have been
blooming. This new technology provides unprecedented opportunities to study disease …
blooming. This new technology provides unprecedented opportunities to study disease …
[HTML][HTML] DUX4, the rockstar of embryonic genome activation?
S Nykänen, S Vuoristo - The International Journal of Developmental …, 2024 - ijdb.ehu.eus
During the initial days of development, the embryo gradually shifts from reliance on
maternally provided RNAs and proteins to regulation of its own development. This transition …
maternally provided RNAs and proteins to regulation of its own development. This transition …
Single-cell analysis reveals conserved regulons shaping muscle stem cell behavior during development and aging in mammals
Z Wang, W Wang, W Li, Y Yao, W Liu… - The Innovation Life, 2024 - the-innovation.org
Muscle stem cells (MuSCs) play a pivotal role in skeletal muscle development, regeneration,
and maintenance. Previous studies have extensively investigated the transcriptional …
and maintenance. Previous studies have extensively investigated the transcriptional …
Transcriptome-wide analysis of cell cycle-dependent bursty gene expression from single-cell RNA-seq data using mechanistic model-based inference
Bursty gene expression is quantified by two intuitive parameters: the burst frequency and the
burst size. While these parameters are known to be cell-cycle dependent for some genes, a …
burst size. While these parameters are known to be cell-cycle dependent for some genes, a …
Deep Learning Based Models for Preimplantation Mouse and Human Development
M Proks, N Salehin, JM Brickman - bioRxiv, 2024 - biorxiv.org
The rapid growth of single-cell transcriptomic technology has produced an increasing
number of datasets for both embryonic development and in vitro pluripotent stem cell …
number of datasets for both embryonic development and in vitro pluripotent stem cell …
RZiMM-scRNA: A regularized zero-inflated mixture model framework for single-cell RNA-seq data
RZiMM-scRNA: A regularized zero-inflated mixture model framework for single-cell RNA-seq
data Page 1 The Annals of Applied Statistics 2024, Vol. 18, No. 1, 1–22 https://doi.org/10.1214/23-AOAS1761 …
data Page 1 The Annals of Applied Statistics 2024, Vol. 18, No. 1, 1–22 https://doi.org/10.1214/23-AOAS1761 …
[PDF][PDF] RNA sequencing and gene co-expression network of in vitro matured oocytes and blastocysts of buffalo
PDPB Santana, K da Costa Pinheiro… - Anim …, 2024 - animal-reproduction.org
In reproductive technologies, uncovering the molecular aspects of oocyte and embryo
competence under different conditions is crucial for refining protocols and enhancing …
competence under different conditions is crucial for refining protocols and enhancing …