[HTML][HTML] Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging

C Liu, L Hua, Z Xin - Redox Biology, 2024 - Elsevier
Objective Our study aims to examine the independent and combined associations of serum
25-hydroxyvitamin D [25 (OH) D] concentrations and physical activity (PA) status with …

Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

CDJ Kusters, KC Paul, AT Lu, L Ferruci, BR Ritz… - GeroScience, 2024 - Springer
Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the
association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers …

Assessing Biological Age: The Potential of ECG Evaluation Using Artificial Intelligence: JACC Family Series

F Lopez-Jimenez, S Kapa, PA Friedman… - Clinical …, 2024 - jacc.org
Biological age may be a more valuable predictor of morbidity and mortality than a person's
chronological age. Mathematical models have been used for decades to predict biological …

Role of oxidative stress in neurodegenerative disorders: A review of reactive oxygen species and prevention by antioxidants

A Houldsworth - Brain Communications, 2024 - academic.oup.com
Neurological disorders include a variety of conditions, including Alzheimer's disease, motor
neuron disease and Parkinson's disease, affecting longevity and quality of life, and their …

Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy

AE Rosko, MI Elsaid, J Woyach, N Islam… - Journal of Cancer …, 2024 - Springer
Purpose Older adults with hematologic malignancies (HM) have unique challenges due to
age and fitness. The primary aim of this pilot study was to benchmark the ability of multiple …

Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals–a randomized intervention trial

KB Michels, AM Binder - Epigenetics, 2024 - Taylor & Francis
Folate is an essential mediator in one-carbon metabolism, which provides methyl groups for
DNA synthesis and methylation. The availability of active methyl groups can be influenced …

The association between methylmalonic acid, a biomarker of mitochondria dysfunction, and phenotypic age acceleration: A population-based study

B Cao, Y Xue, D Liu - Archives of gerontology and geriatrics, 2024 - Elsevier
Phenotypic age acceleration (PAA) is a sensitive marker of biological aging. Circulating
methylmalonic acid (MMA) is a novel biomarker of mitochondrial dysfunction and has been …

[HTML][HTML] Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review

X Tao, Z Zhu, L Wang, C Li, L Sun, W Wang… - Aging and …, 2024 - ncbi.nlm.nih.gov
The risk of developing chronic illnesses and disabilities is increasing with age. To predict
and prevent aging, biomarkers relevant to the aging process must be identified. This paper …

Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing

O Neytchev, H Erlandsson, A Witasp… - Journal of Internal …, 2024 - Wiley Online Library
Background Chronic kidney disease (CKD) is an age‐related disease that displays multiple
features of accelerated ageing. It is currently unclear whether the two treatment options for …

Epigenetic aging of human blood cells is influenced by the age of the host body

P Holland, M Istre, MM Ali, T Gedde‐Dahl… - Aging …, 2024 - Wiley Online Library
Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over
a wide range of donor and recipient age combinations, representing natural experiments of …