The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia
E Macdonald-Laurs, AEL Warren, P Francis… - Brain, 2024 - academic.oup.com
Bottom-of-sulcus dysplasia (BOSD) is increasingly recognized as a cause of drug-resistant,
surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe …
surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe …
[HTML][HTML] Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance
The human brain is organized as segregation and integration units and follows complex
developmental trajectories throughout life. The cortical manifold provides a new means of …
developmental trajectories throughout life. The cortical manifold provides a new means of …
scGHOST: Identifying single-cell 3D genome subcompartments
Abstract Single-cell Hi-C (scHi-C) technologies allow for probing of genome-wide cell-to-cell
variability in three-dimensional (3D) genome organization from individual cells …
variability in three-dimensional (3D) genome organization from individual cells …
[HTML][HTML] Neuroimaging of Parkinson's disease by quantitative susceptibility mapping
Parkinson's disease (PD) is a common neurodegenerative disease, and apart from a few
rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has …
rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has …
[HTML][HTML] Transcriptional cartography integrates multiscale biology of the human cortex
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible …
understand human cortical organization are challenged by reliance on incompatible …
[HTML][HTML] Spatial and temporal pattern of structure–function coupling of human brain connectome with development
Brain structural circuitry shapes a richly patterned functional synchronization, supporting for
complex cognitive and behavioural abilities. However, how coupling of structural …
complex cognitive and behavioural abilities. However, how coupling of structural …
[HTML][HTML] Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic …
Abstract Protocadherin-19 (PCDH19) developmental and epileptic encephalopathy causes
an early-onset epilepsy syndrome with limbic seizures, typically occurring in clusters and …
an early-onset epilepsy syndrome with limbic seizures, typically occurring in clusters and …
[HTML][HTML] Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease
Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer's
disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ …
disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ …
Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain
JW Vogel, AF Alexander-Bloch… - Proceedings of the …, 2024 - National Acad Sciences
Cortical arealization arises during neurodevelopment from the confluence of molecular
gradients representing patterned expression of morphogens and transcription factors …
gradients representing patterned expression of morphogens and transcription factors …
Obesity and the cerebral cortex: Underlying neurobiology in mice and humans
Obesity is a major modifiable risk factor for Alzheimer's disease (AD), characterized by
progressive atrophy of the cerebral cortex. The neurobiology of obesity contributions to AD is …
progressive atrophy of the cerebral cortex. The neurobiology of obesity contributions to AD is …