Emerging Roles of Spatial Transcriptomics in Liver Research

N Fujiwara, G Kimura… - Seminars in Liver Disease, 2024 - thieme-connect.com
Spatial transcriptomics, leveraging sequencing-and imaging-based techniques, has
emerged as a groundbreaking technology for mapping gene expression within the complex …

General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning

JE Moodie, SE Harris, MA Harris… - Human Brain …, 2024 - Wiley Online Library
Gene expression varies across the brain. This spatial patterning denotes specialised
support for particular brain functions. However, the way that a given gene's expression …

Parkinson's disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes

KB Karunakaran, S Jain, SK Brahmachari… - Schizophrenia, 2024 - nature.com
Genome-wide association studies suggest significant overlaps in Parkinson's disease (PD)
and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. The protein …

[HTML][HTML] The landscape of long non-coding RNA expression in the goat brain

E Varela-Martínez, MG Luigi-Sierra, D Guan… - Journal of Dairy …, 2024 - Elsevier
The brain regulates multiple metabolic processes, such as food intake, energy expenditure,
insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose …

Data-driven simulation of network-based tau spreading tailored to individual Alzheimer's patients

SW Kim, H Cho, Y Lee, CH Lyoo, JK Seong - Engineering with Computers, 2024 - Springer
Tau tangles in the brain cortex spread along the brain network in distinct patterns among
Alzheimer's patients. We aim to simulate their network-based spreading within the cortex …

Functional Connectome Hierarchy Distortions in Female Nurses With Occupational Burnout and Its Gene Expression Signatures

Y Shang, Q Su, R Ma, M Chen, Z Zhao… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Burnout has become a serious public health issue worldwide, particularly
during the COVID‐19 pandemic. Functional connectome impairments associated with …

A shifting role of thalamocortical connectivity in the emergence of large-scale functional brain organization across early lifespan development

S Park, KV Haak, S Oldham, H Cho, K Byeon, B Park… - bioRxiv, 2024 - biorxiv.org
While cortical patterning has been a perennial research topic in neuroscience, the
mechanism for its consequence, namely functional specialization at the macro scale …

Functional brain network controllability dysfunction in Alzheimer's disease and its relationship with cognition and gene expression profiling

C Zheng, X Xiao, W Zhao, Z Yang, S Guo… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. In recent studies, network control theory has been applied to clarify transitions
between brain states, emphasizing the significance of assessing the controllability of brain …

Genetic mechanisms underlying local spontaneous brain activity in episodic migraine

W Gui, F Lu, L Fu, Z Deng, X Zhao, W Cheng… - Frontiers in …, 2024 - frontiersin.org
Advances in neuroimaging techniques during the past few decades have captured impaired
functional brain activity in migraine disorders, yet the molecular mechanisms accounting for …

[HTML][HTML] Unravelling the genetic basis of Schizophrenia

C Casey, JF Fullard, RD Sleator - Gene, 2024 - Elsevier
Neuronal development is a highly regulated mechanism that is central to organismal
function in animals. In humans, disruptions to this process can lead to a range of …