A series of novel immunoadjuvant QS-21 analogs were synthesized, and their effects on the
in vitro hemolysis of red blood cells were evaluated using QS-21 as a control and hemolytic …

The saponin natural product QS-21 is one of the most potent investigational adjuvants,
which are substances added to vaccines to enhance the immunogenicity of the antigen and …

Saponins are triterpene glycoside natural products that exhibit many different biological
properties, including activation and modulation of the immune system, and have therefore …

We have synthesized a number of Quillaja saponaria Molina (QS) saponin analogues with a
different C28 sugar unit, which features either 3, 4-diacetyl groups or a 3, 4-cyclic carbonate …

BACKGROUND: Ischemia-reperfusion (I/R) injury occurs in various situations, including
transplantation, trauma, and shock. We previously reported that the synthetic β-SQDG (18 …

QS-21 and QS-7 are two adjuvant-active saponins that can be obtained in high purity from
Quillaja saponaria Molina extracts. QS-21 is a highly characterized compound and is known …

We evaluated the dual immuno-regulatory effects of Y-40138, inhibiting tumor necrosis
factor (TNF)-α production and augmenting interleukin (IL)-10 productions, in animal models …

QS-21 is a triterpene glycoside saponin found in the bark of the Chilean soap bark tree
Quillaja saponaria. It is a highly potent vaccine adjuvant that is included in two approved …

Adjuvant activity of saponins extracted from the South American tree Quillaja saponaria has
been demonstrated with many antigens. Recently, four saponin fractions (designated as QS …

Saponins are natural glycosides of steroid or triterpene which exhibited many different
biological and pharmacological activities. Notably, saponins can also activate the …