Hippocrates, often regarded as the founding figure in empirical medicine, was the first to
acknowledge the impact of environmental factors on general and mental health in his work …

Over recent years, there has been an exponential growth in research into the possible role
of the immune system in major mental illness, but research into immune links to …

There is increasing interest in and evidence for altered immune factors in the etiology and
pathophysiology of schizophrenia. Stimulated by various epidemiological findings reporting …

A growing body of evidence suggests that immune alterations, especially those related to
inflammation, are associated with increased risk of schizophrenia and schizophrenia-related …

Thirty years ago, in a cafe in Helsinki, Sarnoff Mednick and Matti Huttunen contemplated the
conundrum of the season-of-birth effect in schizophrenia. Why were individuals with …

The causes of schizophrenia are unknown; many etiologies have been implicated but none
proven. Renewed interest in immunological etiologies has led investigators to examine the …

Over the recent years, there has been a return to the hypothesis that immune factors are
associated with schizophrenia. At the same time, neuroscience studies have indicated an …

Shatz and colleagues (1) reported in 2000 that a number of immune proteins (cytokines and
major histocompatibility complex [MHC] proteins) were not just present in the brain but were …

Individuals with schizophrenia display substantial deficits in neurocognition, resulting in
poor daily functioning and disability. Recent reports have suggested that neurocognitive …

We propose a unifying hypothesis of schizophrenia to help reconcile findings from many
different disciplines. This hypothesis proposes that schizophrenia often involves pre-or …