Adjuvants are vaccine components that can boost the type, magnitude, breadth, and
durability of an immune response. We have previously demonstrated that certain adjuvant …

Due to functionally distinct cell-mediated immunity, newborns and infants are highly
susceptible to infection with intracellular pathogens. Indeed, neonatal Ag-presenting …

Using adjuvants to drive features of T cell responses to vaccine antigens is an important
technological challenge in the design of new and improved vaccines against infections …

Subunit vaccine formulations often include adjuvants that primarily stimulate innate immune
cells. While young infants represent the major target population for vaccination, effective …

Adjuvants enhance immunity to vaccines and experimental antigens by a variety of
mechanisms. In the past decade, many receptors and signaling pathways in the innate …

Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy
through prolonged retention and sustained release of antigen, lymph node targeting, and …

Infections are most common and most severe at the extremes of age, the young and the
elderly. Vaccination can be a key approach to enhance immunogenicity and protection …

Adjuvants are crucial components of vaccines. They significantly improve vaccine efficacy by
modulating, enhancing, or extending the immune response and at the same time reducing …

Adjuvants are substances that boost the immunogenicity of vaccines. However, most
successful vaccines have been derived empirically and are capable of inducing robust T …

When a wild pathogen enters the body for the first time, it immediately encounters cells of the
innate immune system that are constantly patrolling for invaders. These sentries include …