Attenuated sporozoites provide a valuable model for exploring protective immunity against
the malarial liver stage, guiding the design of highly efficient vaccines to prevent malaria …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

Highlights•Protective immunity against malaria can be achieved through immunisation with
live attenuated Plasmodium sporozoites and targets the parasite pre-erythrocytic …

Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-
Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill
Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination …

Plasmodium falciparum malaria remains one of the most serious health problems globally.
Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

Immunogenicity is considered one important criterion for progression of candidate vaccines
to further clinical evaluation. We tested this assumption in an infection and vaccination …

During the pre-erythrocytic asymptomatic phase of malarial infection, sporozoites develop
transiently inside less than 100 hepatocytes that subsequently release thousands of …