Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

M Wasim, MC Bergonzi - Pharmaceutics, 2024 - mdpi.com
The growing interest in oleanolic acid (OA) as a triterpenoid with remarkable health benefits
prompts an emphasis on its efficient use in pharmaceutical research. OA exhibits a range of …

Development and evaluation of oleanolic acid dosage forms and its derivatives

A Feng, S Yang, Y Sun, L Zhang… - BioMed Research …, 2020 - Wiley Online Library
Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs
and other plants. Because of the extensive pharmacological activity, oleanolic acid has …

Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases

TB Ayeleso, MG Matumba, E Mukwevho - Molecules, 2017 - mdpi.com
The increasing demand for natural products as an alternative therapy for chronic diseases
has encouraged research into the pharmacological importance of bioactive compounds from …

Recent progress in oleanolic acid: structural modification and biological activity

W Wang, Y Li, Y Li, D Sun, H Li… - Current Topics in …, 2022 - ingentaconnect.com
Natural products have been proven as the main source of biologically active compounds,
which are potentially useful for drug development. As one of the most studied pentacyclic …

Recent advances in medicinal chemistry of oleanolic acid derivatives

YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

Application and Development of Natural Plant Metabolite Oleanolic Acid in the Nano Era

K Wang, Q Lu, X Cao, Y Wang, Y Wu, Z Chen, Z Yang - Agriculture, 2022 - mdpi.com
Like other pentacyclic triterpenoids, oleanolic acid, a natural plant metabolite prevalent in
plant peels, stems, and leaves, is regarded as a possible drug candidate. A growing number …

Oleanolic acid derivatives for pharmaceutical use: A patent review

C Lin, X Wen, H Sun - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: Oleanolic acid belongs to the pentacyclic triterpene family. In China, oleanolic
acid has been used as an over the counter (OTC) hepatoprotective drug for decades …

A review of structural modification and biological activities of oleanolic acid

Y Huali, D Minghui, JIA Hongwei, K Zhang… - Chinese Journal of …, 2024 - Elsevier
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological
activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective …

The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

D Camer, Y Yu, A Szabo… - Molecular nutrition & food …, 2014 - Wiley Online Library
Recent research has uncovered the molecular mechanisms responsible for the therapeutic
properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …